It's as ease as 1 - 2 - 3!
Sign up for an acccount here, and download the trial version of MDebug and give it a try! Develop your Mono applications despite if you want to debug locally or on a remote target like an embedded device.
Choose what you want
You have the choise with MDebug - developing against the big, mature Microsoft .NET Framework, run it within the Mono environment or use the Mono Profile!
Because MDebug is integrating full into Microsoft Visual Studio you have the power of any extension you love to use within the environment.